Our Technology

The letters “BiomACS” stand for “Biomaterial Advanced Cell Screening”. This system was developed to study the interaction between medical materials and cells, which is essential for developing optimized medical devices. Our advanced screening technology, developed in collaboration with experts in materials science, chemistry, cell biology, and clinical practice, enables the detailed analysis of how cells respond to different surface properties. These insights are crucial for developing advanced medical devices, such as bioactive cardiovascular stents, which not only improve patients’ quality of life but also reduce healthcare costs by decreasing the number of revision surgeries and hospitalizations.

Measuring gradients instead of points

The key difference that BiomACS makes is that we measure gradients To maximize our understanding of how cells respond to multiple material parameters simultaneously, we utilize patented technology. While a conventional experiment will only provide information about one specific combination of parameters, a gradient can offer insights into all variations of a single parameter between a minimum and a maximum. BiomACS applies an orthogonal gradient approach that provides information between the minimum and maximum values of two parameters. This yields vastly more data without increasing the number of experiments; after all, we are still dealing with just a single sample. This allows us to conduct thousands of experiments at once.

Testing and modifying materials with 4 substrates and thousands of conditions at once

BiomACS technology utilizes four double orthogonal gradients, with chemistry, topography, and stiffness as the varying parameters. A single experiment replaces thousands of individual in vitro experiments, making this approach particularly time- and cost-efficient. The efficient approach to cell-material interaction using BiomACS technology is combined with high-throughput imaging and data analysis to efficiently process the vast amounts of data. From start to finish, the process is focused on reproducibility, high content, and high throughput, providing insights into how materials should be modified or what properties are needed to produce customized medical implants that result in significantly fewer secondary medical complications.

Biomacs tech

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