Surface optimization of stents
In this SNN-EFRO project, BiomACS’s screening technology has made the transition from in vitro screening to in vivo pre-clinically validated new cardiovascular stents. BiomACS is collaborating with UMCG Surgery, Biomedical Technology, and Bentley to develop a new endovascular stent graft that minimizes secondary complications such as leakage and displacement.
BiomACS’s screening technology has tested combinations of PTFE surface properties, such as hydrophobicity and topography, for their influence on cell behavior. The most optimal properties were then translated into an endovascular stent and validated using an animal model. The goal is to develop a PTFE endovascular stent with an optimized surface that actively stimulates adhesion to the vessel wall. This project has been successfully completed; cell adhesion to the stent has been stimulated following treatment with BiomACS.
This project is subsidized by SNN-EFRO.
With the SNN grant, we have been able to carry out this project, bringing BiomACS’s screening technology for optimal medical materials into its next phase.
