Gradients make the difference
To maximize the amount of insights on how cells respond to multiple material parameter inputs simultaneously we make use of proprietary technology. While conventional experiment will provide information on one specific combination of paratemers (a dot in the box), a gadient would provide insights into all variations on one parameter between a minimum and a maximum (line in the box). BiomACS uses an orthogonal gradient approach that provides information between a minimum and maximum value of two parameters (plane in the box). This provides tremendously more data without increasing the amount of experiments, this is still only one sample.
Four substrates, thousands of conditions
The BiomACS technology uses four double orthogonal gradients using chemistry, topography, and stiffness as the varying parameters. One experiments replaces thousands of individual in vitro experiments making the approach highly time and cost efficient.
The efficient cell-material interaction approach using the BiomACS technology is coupled to high-throughput imaging and data analysis to efficiently process the enormous amounts of data. From beginning to end, the process is focussed on reproducibility, high-content, high-throughput that allows to gain insights in how materials should be adapted or what properties are needed to produce tailor-made medical implants that have vastly reduced secondary medical complications.